Yes, a good routine is to use it as a toner last thing at night, and then again in the morning just before applying make-up, making sure it is dry before you put anything on top of it.This can vary. We have many customers who have seen a clear result in 2-3 days, whereas some others have taken 2-3 weeks. On average you should see a real difference in 7-8 days.Yes, Quintessence will continue to work underneath your make up. However, please be sure to give it a few moments to dry thoroughly on your skin, before applying any make up or moisturisers.Quintessence should be applied, using a cotton pad, to the affected areas twice a day. We suggest using it as a toner at night before bed, and then again in the morning after washing and before applying any make up or moisturisers. It must be applied to clean dry bare...As Quintessence needs to be in contact with your clean dry skin to work effectively, any other treatment may well interfere with this contact and reduce Skinetica’s efficacy, we recommend that you use it without any other treatments.